With financial support from the National Institute of Health's (NIH) Director's Opportunity for Research awards using American Reinvestment and Recovery Act funds (RC2 AG036495-01, RC4 AG039029-01), the HRS has genotyped almost 20,000 respondents who provided DNA samples and signed consent forms in 2006-2012.
The addition of genetic data provides a major new dimension for the study and is expected to result in much deeper insights into how we age," said Richard Hodes, director of the National Institute on Aging. "With detailed information on genetic background, combined with the wealth of data on important aspects of the lives of older people, researchers will be better able to describe the spectrum of behavioral and environmental risk factors for disease and disability, as well as those that may protect our health."
Several genetic data products derived from these samples are available. Data are distributed through the NCBI Database of Genotypes and Phenotypes (dbGaP), the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), and through the HRS web site.
Available from dbGaP
Available from NIAGADS
- Genotype Data Version 3 (2006-2012 samples) (New)
- Genotype Data Version 4 (2006-2016 samples) (Forthcoming)
Available from HRS
- APOE and Serotonin Transporter Alleles
- Candidate gene and SNP files
- Epigenetic Clocks
- Exome Data (2006-2010)
- Polygenic Score Data (PGS)
- 2008 Telomere Data
Video Tutorials
Two video tutorials provide an overview of HRS Genetic Data and the application/download process:
Training
Genomics for Social Scientists
A one-week genomic data workshop focused on providing hands-on training for researchers working at the intersection of genetics and social science research, using data from the Health and Retirement Study (HRS) as a model. View workshop website
Additional Information
- HRS study page on dbGaP site
- Summary of Data Products
- HumanOmni 2.5 Beadchip Datasheet
- HumanOmni 2.5-Quad Product Files
- NIH Center for Inherited Disease Research
- Quality Control Report for 2006-2008 Genotypic Data
- Quality Control Report for 2006-2010 Genotypic Data
- 1000Genomes Project
- Imputation Report for 2006-2008 Genotypic Data - 1000 Genomes Project Reference Panel
- Imputation Report for 2006-2010 Genotypic Data - 1000 Genomes Project Reference Panel
- NCBI dbGaP