Bayesian variable selection in linear quantile mixed models for longitudinal data with application to macular degeneration.

TitleBayesian variable selection in linear quantile mixed models for longitudinal data with application to macular degeneration.
Publication TypeJournal Article
Year of Publication2020
AuthorsJi, Y, Shi, H
JournalPLoS One
Volume15
Issue10
Paginatione0241197
ISSN Number1932-6203
KeywordsBayes Theorem, Computer Simulation, Datasets as Topic, Linear Models, Longitudinal Studies, Macular Degeneration
Abstract

This paper presents a Bayesian analysis of linear mixed models for quantile regression based on a Cholesky decomposition for the covariance matrix of random effects. We develop a Bayesian shrinkage approach to quantile mixed regression models using a Bayesian adaptive lasso and an extended Bayesian adaptive group lasso. We also consider variable selection procedures for both fixed and random effects in a linear quantile mixed model via the Bayesian adaptive lasso and extended Bayesian adaptive group lasso with spike and slab priors. To improve mixing of the Markov chains, a simple and efficient partially collapsed Gibbs sampling algorithm is developed for posterior inference. Simulation experiments and an application to the Age-Related Macular Degeneration Trial data to demonstrate the proposed methods.

DOI10.1371/journal.pone.0241197
Citation Key12457
PubMed ID33104698
PubMed Central IDPMC7588124