Title | Antigenic challenge in the etiology of autoimmune disease in women. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Rogers, MAM, Levine, DA, Blumberg, N, Fisher, GG, Kabeto, MU, Langa, KM |
Journal | J Autoimmun |
Volume | 38 |
Issue | 2-3 |
Pagination | J97-J102 |
Date Published | 2012 May |
ISSN Number | 1095-9157 |
Keywords | Aged, Aged, 80 and over, Antigens, Autoimmune Diseases, Female, Humans, Incidence, Middle Aged, Prevalence, Risk Factors, United States |
Abstract | Infection has long been implicated as a trigger for autoimmune disease. Other antigenic challenges include receipt of allogeneic tissue or blood resulting in immunomodulation. We investigated antigenic challenges as possible risk factors for autoimmune disease in women using the Health and Retirement Study, a nationally representative longitudinal study, linked to Medicare files, years 1991-2007. The prevalence of autoimmune disease (rheumatoid arthritis, Hashimoto's disease, Graves' disease, systemic lupus erythematosus, celiac disease, systemic sclerosis, Sjögren syndrome and multiple sclerosis) was 1.4% in older women (95% CI: 1.3%, 1.5%) with significant variation across regions of the United States. The risk of autoimmune disease increased by 41% (95% CI of incidence rate ratio (IRR): 1.10, 1.81) with a prior infection-related medical visit. The risk of autoimmune disease increased by 90% (95% CI of IRR: 1.36, 2.66) with a prior transfusion without infection. Parity was not associated with autoimmune disease. Women less than 65 years of age and Jewish women had significantly elevated risk of developing autoimmune disease, as did individuals with a history of heart disease or end-stage renal disease. Antigenic challenges, such as infection and allogeneic blood transfusion, are significant risk factors for the development of autoimmune disease in older women. |
Notes | Rogers, Mary A M Levine, Deborah A Blumberg, Neil Fisher, Gwenith G Kabeto, Mohammed Langa, Kenneth M 5R21HL093129-02/HL/NHLBI NIH HHS/ HL078603/HL/NHLBI NIH HHS/ HL095467/HL/NHLBI NIH HHS/ HL100051/HL/NHLBI NIH HHS/ R21 HL093129-01A1/HL/NHLBI NIH HHS/ R21 HL093129-02/HL/NHLBI NIH HHS/ U01AG009740/AG/NIA NIH HHS/ England J Autoimmun. 2012 May;38(2-3):J97-J102. Epub 2011 Aug 30. |
DOI | 10.1016/j.jaut.2011.08.001 |
User Guide Notes | |
Endnote Keywords | infection/autoimmune disease/allogeneic blood transfusion/risk Factors/WOMEN |
Endnote ID | 69458 |
Alternate Journal | J Autoimmun |
Citation Key | 7713 |
PubMed ID | 21880464 |
PubMed Central ID | PMC3242155 |
Grant List | R21 HL093129-02 / HL / NHLBI NIH HHS / United States R21 HL093129 / HL / NHLBI NIH HHS / United States R01 HL095467 / HL / NHLBI NIH HHS / United States HL095467 / HL / NHLBI NIH HHS / United States HL100051 / HL / NHLBI NIH HHS / United States R21 HL093129-01A1 / HL / NHLBI NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States RC1 HL100051 / HL / NHLBI NIH HHS / United States 5R21HL093129-02 / HL / NHLBI NIH HHS / United States R01 HL078603 / HL / NHLBI NIH HHS / United States U01AG009740 / AG / NIA NIH HHS / United States HL078603 / HL / NHLBI NIH HHS / United States |