Title | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Okbay, A, Baselmans, BML, De Neve, J-E, Turley, P, Nivard, MG, Fontana, MAlan, S Meddens, FW, Linnér, RKarlsson, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, de Vlaming, R, Ahluwalia, TS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V, Geisel, MHenrike, Gonzalez, JR, Haitjema, S, Karlsson, R, van der Laan, SW, Ladwig, K-H, Lahti, J, van der Lee, SJ, Lind, PA, Liu, T, Matteson, LK, Mihailov, E, Miller, MB, Minica, CC, Nolte, IM, Mook-Kanamori, DO, van der Most, PJ, Oldmeadow, CJ, Qian, Y, Raitakari, OT, Rawal, R, Realo, A, Rueedi, R, Schmidt, B, Smith, AVernon, Stergiakouli, E, Tanaka, T, Taylor, KD, Wedenoja, J, Wellmann, J, Westra, H-J, Willems, SM, Zhao, W, Amin, N, Bakshi, A, Boyle, PA, Cherney, S, Cox, SR, Davies, G, Davis, OSP, Ding, J, Direk, N, Eibich, P, Emeny, RT, Fatemifar, G, Faul, J, Ferrucci, L, Forstner, AJ, Gieger, C, Gupta, R, Harris, TB, Harris, JM, Holliday, EG, Hottenga, J-J, de Jager, PL, Kaakinen, MA, Kajantie, E, Karhunen, V, Kolcic, I, Kumari, M, Launer, LJ, Franke, LL, Li-Gao, R, Koini, M, Loukola, A, Marques-Vidal, P, Montgomery, GW, Mosing, MA, Paternoster, L, Pattie, A, Petrovic, KE, Pulkki-Raback, L, Quaye, L, Räikkönen, K, Rudan, I, Scott, RJ, Smith, JA, Sutin, AR, Trzaskowski, M, Vinkhuyzen, AAE, Yu, L, Zabaneh, D, Attia, JR, Bennett, DA, Berger, K, Bertram, L, Boomsma, DI, Snieder, H, Chang, S-C, Cucca, F, Deary, IJ, van Duijn, CM, Eriksson, JG, Bültmann, U, de Geus, EJC, Groenen, PJF, Gudnason, V, Hansen, T, Hartman, CA, Haworth, CMA, Hayward, C, Heath, AC, Hinds, DA, Hyppönen, E, Iacono, WG, Järvelin, M-R, Jöckel, K-H, Kaprio, J, Kardia, SLR, Keltikangas-Järvinen, L, Kraft, P, Kubzansky, LD, Lehtimäki, T, Magnusson, PKE, Martin, NG, McGue, M, Metspalu, A, Mills, MC, de Mutsert, R, Oldehinkel, AJ, Pasterkamp, G, Pedersen, NL, Plomin, R, Polasek, O, Power, C, Rich, SS, Rosendaal, FR, den Ruijter, HM, Schlessinger, D, Schmidt, H, Svento, R, Schmidt, R, Alizadeh, BZ, Sørensen, TIA, Spector, T, Steptoe, A, Terracciano, A, A. Thurik, R, Timpson, NJ, Tiemeier, H, Uitterlinden, AG, Vollenweider, P, Wagner, GG, Weir, DR, Yang, J, Conley, DC, Hofman, A, Johannesson, M, Laibson, DI, Medland, SE, Meyer, MN, Pickrell, JK, Esko, T, Krueger, RF, Beauchamp, JP, Koellinger, PD, Benjamin, DJ, Bartels, M, Cesarini, D |
Corporate Authors | LifeLines Cohort Study |
Journal | Nat Genet |
Volume | 48 |
Issue | 6 |
Pagination | 624-33 |
Date Published | 2016 06 |
ISSN Number | 1546-1718 |
Keywords | Anxiety Disorders, Bayes Theorem, depression, Genome-Wide Association Study, Humans, Neuroticism, Phenotype, Polymorphism, Single Nucleotide |
Abstract | Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. |
DOI | 10.1038/ng.3552 |
User Guide Notes | |
Alternate Journal | Nat. Genet. |
Citation Key | 8618 |
PubMed ID | 27089181 |
PubMed Central ID | PMC4884152 |
Grant List | R01 DA036216 / DA / NIDA NIH HHS / United States G1001799 / / Medical Research Council / United Kingdom RF1 AG015819 / AG / NIA NIH HHS / United States U01 AG009740 / AG / NIA NIH HHS / United States MC_UU_12013/3 / / Medical Research Council / United Kingdom MC_QA137853 / / Medical Research Council / United Kingdom R01 AG017917 / AG / NIA NIH HHS / United States MR/J012165/1 / / Medical Research Council / United Kingdom R03 AG051960 / AG / NIA NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States MR/K026992/1 / / Medical Research Council / United Kingdom MR/N01104X/1 / / Medical Research Council / United Kingdom P30 DK063491 / DK / NIDDK NIH HHS / United States P2C HD047879 / HD / NICHD NIH HHS / United States MC_PC_15018 / / Medical Research Council / United Kingdom P30 AG010161 / AG / NIA NIH HHS / United States MC_UU_12013/1 / / Medical Research Council / United Kingdom MC_PC_U127561128 / / Medical Research Council / United Kingdom P01 AG005842 / AG / NIA NIH HHS / United States R37 DA005147 / DA / NIDA NIH HHS / United States P30 AG012810 / AG / NIA NIH HHS / United States R01 AG042568 / AG / NIA NIH HHS / United States T32 AG000186 / AG / NIA NIH HHS / United States 647648 / / European Research Council / International |