Title | Genome-wide analysis identifies 12 loci influencing human reproductive behavior. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Barban, N, Jansen, R, de Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, van der Laan, SW, Perry, JRB, Kong, A, Ahluwalia, TS, Albrecht, E, Yerges-Armstrong, LM, Atzmon, G, Auro, K, Ayers, KL, Bakshi, A, Ben-Avraham, D, Berger, K, Bergman, A, Bertram, L, Bielak, LF, Bjornsdottir, G, Bonder, MJan, Broer, L, Bui, M, Barbieri, C, Cavadino, A, Chavarro, JE, Turman, C, Concas, MPina, Cordell, HJ, Davies, G, Eibich, P, Eriksson, N, Esko, T, Eriksson, J, Falahi, F, Felix, JF, Fontana, MAlan, Franke, LL, Gandin, I, Gaskins, AJ, Gieger, C, Gunderson, EP, Guo, X, Hayward, C, He, C, Hofer, E, Huang, H, Joshi, PK, Kanoni, S, Karlsson, R, Kiechl, S, Kifley, A, Kluttig, A, Kraft, P, Lagou, V, Lecoeur, C, Lahti, J, Li-Gao, R, Lind, PA, Liu, T, Makalic, E, Mamasoula, C, Matteson, LK, Mbarek, H, McArdle, PF, McMahon, G, S Meddens, FW, Mihailov, E, Miller, MB, Missmer, SA, Monnereau, C, van der Most, PJ, Myhre, R, Nalls, MA, Nutile, T, Kalafati, IPanagiota, Porcu, E, Prokopenko, I, Rajan, KB, Rich-Edwards, J, Rietveld, CA, Robino, A, Rose, LM, Rueedi, R, Ryan, KA, Saba, Y, Schmidt, D, Smith, JA, Stolk, L, Streeten, E, Tönjes, A, Thorleifsson, G, Ulivi, S, Wedenoja, J, Wellmann, J, Willeit, P, Yao, J, Yengo, L, Zhao, JHua, Zhao, W, Zhernakova, DV, Amin, N, Andrews, H, Balkau, B, Barzilai, N, Bergmann, S, Biino, G, Bisgaard, H, Bønnelykke, K, Boomsma, DI, Buring, JE, Campbell, H, Cappellani, S, Ciullo, M, Cox, SR, Cucca, F, Toniolo, D, Davey-Smith, G, Deary, IJ, Dedoussis, G, Deloukas, P, van Duijn, CM, de Geus, EJC, Eriksson, JG, Faul, J, Sala, CFelicita, Froguel, P, Gasparini, PP, Girotto, GG, Grabe, H-J, Greiser, KHalina, Groenen, PJF, de Haan, HG, Haerting, J, Harris, TB, Heath, AC, Heikkilä, K, Hofman, A, Homuth, G, Holliday, EG, Hopper, JL, Hyppönen, E, Jacobsson, B, Jaddoe, V, Johannesson, M, Jugessur, A, Kähönen, M, Kajantie, E, Kardia, SLR, Keavney, B, Kolcic, I, Koponen, P, Kovacs, P, Kronenberg, F, Kutalik, Z, La Bianca, M, Lachance, G, Iacono, WG, Lai, S, Lehtimäki, T, Liewald, DC, Lindgren, CM, Liu, Y, Luben, R, Lucht, M, Luoto, R, Magnus, P, Magnusson, PKE, Martin, NG, McGue, M, McQuillan, R, Medland, SE, Meisinger, C, Mellström, D, Metspalu, A, Traglia, M, Milani, L, Mitchell, P, Montgomery, GW, Mook-Kanamori, DO, de Mutsert, R, Nohr, EA, Ohlsson, C, Olsen, J, Ong, KK, Paternoster, L, Pattie, A, Penninx, BWJH, Perola, M, Peyser, PA, Pirastu, M, Polasek, O, Power, C, Kaprio, J, Raffel, LJ, Räikkönen, K, Raitakari, OT, Ridker, PM, Ring, SM, Roll, K, Rudan, I, Ruggiero, D, Rujescu, D, Salomaa, V, Schlessinger, D, Schmidt, H, Schmidt, R, Schupf, N, Smit, JH, Sorice, R, Spector, T, Starr, JM, Stöckl, D, Strauch, K, Stumvoll, M, Swertz, MA, Thorsteinsdottir, U, A. Thurik, R, Timpson, NJ, Tung, JY, Uitterlinden, AG, Vaccargiu, S, Viikari, J, Vitart, V, Völzke, H, Vollenweider, P, Vuckovic, D, Waage, J, Wagner, GG, Wang, JJin, Wareham, NJ, Weir, DR, Willemsen, G, Willeit, J, Wright, AF, Zondervan, KT, Stefansson, K, Krueger, RF, Lee, JJ, Benjamin, DJ, Cesarini, D, Koellinger, PD, Hoed, Mden, Snieder, H, Mills, MC |
Corporate Authors | BIOS Consortium, LifeLines Cohort Study |
Journal | Nat Genet |
Volume | 48 |
Issue | 12 |
Pagination | 1462-1472 |
Date Published | 2016 Dec |
ISSN Number | 1546-1718 |
Abstract | The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits. |
DOI | 10.1038/ng.3698 |
User Guide Notes | |
Alternate Journal | Nat. Genet. |
Citation Key | 8881 |
PubMed ID | 27798627 |
PubMed Central ID | PMC5695684 |
Grant List | G1001799 / / Medical Research Council / United Kingdom RG/15/12/31616 / / British Heart Foundation / United Kingdom R01 AG051635 / AG / NIA NIH HHS / United States MC_UU_12013/3 / / Medical Research Council / United Kingdom SDR 10-012 / HX / HSRD VA / United States Z99 AG999999 / / Intramural NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States MR/J012165/1 / / Medical Research Council / United Kingdom UL1 TR000124 / TR / NCATS NIH HHS / United States MR/K026992/1 / / Medical Research Council / United Kingdom MC_PC_U127561128 / / Medical Research Council / United Kingdom P30 AG038072 / AG / NIA NIH HHS / United States P01 AG005842 / AG / NIA NIH HHS / United States UL1 TR001881 / TR / NCATS NIH HHS / United States / / Wellcome Trust / United Kingdom P30 AG012810 / AG / NIA NIH HHS / United States R01 AG042568 / AG / NIA NIH HHS / United States T32 AG000186 / AG / NIA NIH HHS / United States 615603 / / European Research Council / International G9815508 / / Medical Research Council / United Kingdom 647648 / / European Research Council / International |