@article {11364, title = {Genetic Association Studies of Age-Related Traits: New Perspectives}, journal = {Advances in Geriatric Medicine and Research}, volume = {3}, year = {2021}, pages = {e210003}, abstract = {Understanding the role of genetic factors in non-Mendelian traits characteristic for post-reproductive life, herein referred to as age-related traits, is lagged behind the understanding of the genetic architecture of Mendelian traits. This lag calls for new, more comprehensive approaches in the analyses of age-related traits leveraging their characteristic features. This paper discusses the role of the inherent heterogeneity in genetic predisposition to age-related traits and pleiotropy. It shows that the comprehensive analyses leveraging such heterogeneity can substantially increase the efficiency and accelerate the progress in uncovering genetic predisposition to such traits.}, keywords = {age-related traits, Aging, Genetic Association Studies, GWAS, Pleiotropy}, doi = {https://doi.org/10.20900/agmr20210003}, author = {Alexander M Kulminski} }