@article {9429,
	title = {Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies.},
	journal = {Int J Environ Res Public Health},
	volume = {14},
	year = {2017},
	abstract = {Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors.},
	keywords = {Blood pressure, Genetics, GWAS, Meta-analyses, Psychosocial, Socioeconomic factors},
	issn = {1660-4601},
	doi = {10.3390/ijerph14121596},
	author = {Wei Zhao and Yasutake, Kalyn and August, Carmella and Scott M Ratliff and Jessica Faul and Boerwinkle, Eric and Chakravarti, Aravinda and Ana V. Diez-Roux and Gao, Yan and Michael E Griswold and Gerardo Heiss and Sharon L R Kardia and Alanna C Morrison and Musani, Solomon K and Mwasongwe, Stanford and Kari E North and Rose, Kathryn M and Sims, Mario and Yan V Sun and David R Weir and Belinda L Needham}
}
