@article {12046, title = {The association between obstructive sleep apnea risk and cognitive disorders: A population-based study.}, journal = {Journal of Clinical Sleep Medicine}, volume = {18}, year = {2022}, pages = {1177-1185}, abstract = {

STUDY OBJECTIVES: To examine the association between OSA risk and cognitive disorders among US adults.

METHODS: Data from the 2016 wave of the Health and Retirement Study (HRS) were utilized. Probable OSA cases were identified with survey items that resembled critical elements of a clinically validated OSA screen (STOP-Bang questionnaire). Weighted prevalence of cognitive impairment not dementia (CIND) and dementia among individuals with and without probable OSA were assessed. Cross-sectional analyses of associations between OSA risk and cognitive outcomes, along with effect modification by race and ethnicity, were estimated using imputed data.

RESULTS: Of the 20,910 HRS participants, 60\% had probable OSA. CIND and dementia were more common among adults with probable OSA as compared to those without (12.7\% vs. 8.0\% for CIND; 3.2\% vs 2.0\% for dementia). Probable OSA was associated with CIND (OR=1.22, 1.08-1.37) and dementia (OR=1.27, 1.04-1.54). Race/ethnicity significantly modified the association between probable OSA and CIND, with a higher risk for CIND in Whites (OR=1.35, 1.17-1.57) as compared to non-Whites (OR=0.98, 0.81-1.19).

CONCLUSIONS: CIND and dementia are more common among older adults who are at high risk for OSA, as compared to low-risk individuals. These data highlight the importance of consideration of OSA risk in large-scale studies of OSA and cognitive disorders.

}, keywords = {cognitive disorders, Dementia, effect modification, obstructive sleep apnea}, issn = {1550-9397}, doi = {10.5664/jcsm.9832}, author = {Shieu, Monica M and Galit L Dunietz and Paulson, Henry L and Ronald D Chervin and Braley, Tiffany J} }