TY - JOUR T1 - The Influence of the Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes. JF - Clinical Nursing Research Y1 - 2022 A1 - Zeng, Bin A1 - Yue, Yan A1 - Liu, Tingting A1 - Ahn, Hyochol A1 - Li, Changwei KW - Brain-Derived Neurotrophic Factor KW - Depressive symptoms KW - Diabetes KW - Grip strength KW - Physical activity AB -

The rs6265 in the (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = -.15) and stronger grip strength (β = -.02) were independently associated with depression. Although the interaction between rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = -.19) and male Met carriers (β = -.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = -.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.

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