TY - JOUR T1 - Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. JF - Int J Environ Res Public Health Y1 - 2017 A1 - Wei Zhao A1 - Yasutake, Kalyn A1 - August, Carmella A1 - Scott M Ratliff A1 - Jessica Faul A1 - Boerwinkle, Eric A1 - Chakravarti, Aravinda A1 - Ana V. Diez-Roux A1 - Gao, Yan A1 - Michael E Griswold A1 - Gerardo Heiss A1 - Sharon L R Kardia A1 - Alanna C Morrison A1 - Musani, Solomon K A1 - Mwasongwe, Stanford A1 - Kari E North A1 - Rose, Kathryn M A1 - Sims, Mario A1 - Yan V Sun A1 - David R Weir A1 - Belinda L Needham KW - Blood pressure KW - Genetics KW - GWAS KW - Meta-analyses KW - Psychosocial KW - Socioeconomic factors AB - Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors. VL - 14 IS - 12 U1 - http://www.ncbi.nlm.nih.gov/pubmed/29258278?dopt=Abstract ER -