TY - JOUR T1 - The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States. JF - Biological Research for Nursing Y1 - 2022 A1 - Liu, Tingting A1 - Li, Hongjin A1 - Conley, Yvette P A1 - Primack, Brian A A1 - Wang, Jing A1 - Li, Changwei KW - Brain-Derived Neurotrophic Factor KW - Cognition KW - Exercise KW - Gene-Environment Interaction KW - Hand Strength AB -

INTRODUCTION: Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA).

METHODS: A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition.

RESULTS: Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, = .07), mental status (beta = 0.16, = .07), and word recall (beta = 0.22, =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = -0.09, = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model.

CONCLUSIONS: The Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

VL - 24 IS - 2 ER - TY - JOUR T1 - The Influence of the Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes. JF - Clinical Nursing Research Y1 - 2022 A1 - Zeng, Bin A1 - Yue, Yan A1 - Liu, Tingting A1 - Ahn, Hyochol A1 - Li, Changwei KW - Brain-Derived Neurotrophic Factor KW - Depressive symptoms KW - Diabetes KW - Grip strength KW - Physical activity AB -

The rs6265 in the (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = -.15) and stronger grip strength (β = -.02) were independently associated with depression. Although the interaction between rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = -.19) and male Met carriers (β = -.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = -.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.

ER - TY - JOUR T1 - The Influence of the BDNFVal66Met Polymorphism on the Association of Regular Physical Activity With Cognition Among Individuals With Diabetes. JF - Biological Research for Nursing Y1 - 2020 A1 - Liu, Tingting A1 - Canon, McKenzie D A1 - Shen, Luqi A1 - Marples, Benjamin A A1 - Colton, Joseph P A1 - Lo, Wen-Juo A1 - Gray, Michelle A1 - Li, Changwei KW - Brain-Derived Neurotrophic Factor KW - Cognition KW - Diabetes Mellitus KW - Exercise KW - Gene-Environment Interaction AB -

INTRODUCTION: Diabetes is associated with cognitive dysfunction that comes with substantial lifetime consequences, such as interference with diabetes self-management and reduced quality of life. Although regular physical activity has been consistently shown to enhance cognitive function among healthy subjects, significant interpersonal differences in exercise-induced cognitive outcomes have been reported among (BDNF) Val/Val vs. Met carriers. However, the evidence on how the Val66Met variant influences the relationship between regular physical activity and cognition among individuals with diabetes is currently lacking.

METHODS: A total of 3,040 individuals with diabetes were included in this analysis using data from the Health and Retirement Study. Associations among moderate and vigorous physical activities (MVPA) and measures of cognitive function were evaluated using multivariable linear regression models within each stratum of the Val66Met genotypes.

RESULTS: MVPA was more strongly associated with total cognitive score, mental status, and words recall among Met/Met carriers, compared to Val/Val and Val/Met carriers.

CONCLUSIONS: This study provided preliminary findings on how variants may modulate the exercise-induced cognitive benefits among mid-aged and older adults with diabetes. Given the limitations of the current study, it is necessary for randomized controlled trials to stratify by genotypes to more conclusively determine whether Met carriers benefit more from increased physical activity. In addition, future research is needed to examine how the interplay of Val66Met variants, DNA methylation, and physical activity may have an impact on cognitive function among adults with diabetes.

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