%0 Journal Article %J Clinical Nursing Research %D 2022 %T The Influence of the Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes. %A Zeng, Bin %A Yue, Yan %A Liu, Tingting %A Ahn, Hyochol %A Li, Changwei %K Brain-Derived Neurotrophic Factor %K Depressive symptoms %K Diabetes %K Grip strength %K Physical activity %X

The rs6265 in the (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = -.15) and stronger grip strength (β = -.02) were independently associated with depression. Although the interaction between rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = -.19) and male Met carriers (β = -.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = -.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.

%B Clinical Nursing Research %G eng %R 10.1177/10547738221119343