%0 Journal Article %J Obesity (Silver Spring) %D 2016 %T Trajectories of body mass indices and development of frailty: Evidence from the health and retirement study. %A Briana Mezuk %A Matthew C. Lohman %A Rock, Andrew K %A Payne, Martha E %K Aged %K Aged, 80 and over %K Body Mass Index %K Body Weight %K Female %K Frail Elderly %K Geriatric Assessment %K Health Status %K Humans %K Incidence %K Longitudinal Studies %K Male %K Obesity %K Retirement %K Risk Factors %K Weight Gain %X

OBJECTIVE: To estimate trajectories of body mass index (BMI) and determine their association with incident frailty in later life.

METHODS: Data come from the 2004 to 2012 waves of the Health and Retirement Study, a longitudinal survey of older adults. Analysis was restricted to respondents who were not frail at baseline (n = 10,827). BMI (kg/m(2) ) was calculated from self-reported weight and height. Incident frailty was assessed using the Frailty Index. Longitudinal growth mixture modeling was used to estimate the relationship between BMI trajectories and incident frailty over a 10-year period.

RESULTS: Four trajectory classes were identified: weight gain (n = 162 [1.4%], mean final BMI = 42 kg/m(2) ), weight loss (n = 171 [1.7%], mean final BMI = 25.0 kg/m(2) ), consistent obesity (n = 640 [6.8%], mean final BMI = 34.7 kg/m(2) ), and consistent overweight (n = 9,864 [90.1%] mean final BMI = 26.0 kg/m(2) ). Cumulative incidence of frailty was 19.9%. Relative to the consistent overweight class, the weight gain class had the highest likelihood of incident frailty (odds ratio, OR: 3.61, 95% confidence interval, CI: 2.39-5.46). The consistent obesity (OR: 2.72, 95% CI: 2.06-3.58) and weight loss (OR: 2.81, 95% CI: 1.84-4.30) classes had similarly elevated risk of frailty.

CONCLUSIONS: Weight change and obesity are associated with risk of frailty.

%B Obesity (Silver Spring) %V 24 %P 1643-7 %8 2016 08 %G eng %U http://www.ncbi.nlm.nih.gov/pubmed/27355440 %N 8 %1 http://www.ncbi.nlm.nih.gov/pubmed/27355440?dopt=Abstract %R 10.1002/oby.21572