%0 Journal Article %J Int J Environ Res Public Health %D 2017 %T Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. %A Wei Zhao %A Yasutake, Kalyn %A August, Carmella %A Scott M Ratliff %A Jessica Faul %A Boerwinkle, Eric %A Chakravarti, Aravinda %A Ana V. Diez-Roux %A Gao, Yan %A Michael E Griswold %A Gerardo Heiss %A Sharon L R Kardia %A Alanna C Morrison %A Musani, Solomon K %A Mwasongwe, Stanford %A Kari E North %A Rose, Kathryn M %A Sims, Mario %A Yan V Sun %A David R Weir %A Belinda L Needham %K Blood pressure %K Genetics %K GWAS %K Meta-analyses %K Psychosocial %K Socioeconomic factors %X Inter-individual variability in blood pressure (BP) is influenced by both genetic and non-genetic factors including socioeconomic and psychosocial stressors. A deeper understanding of the gene-by-socioeconomic/psychosocial factor interactions on BP may help to identify individuals that are genetically susceptible to high BP in specific social contexts. In this study, we used a genomic region-based method for longitudinal analysis, Longitudinal Gene-Environment-Wide Interaction Studies (LGEWIS), to evaluate the effects of interactions between known socioeconomic/psychosocial and genetic risk factors on systolic and diastolic BP in four large epidemiologic cohorts of European and/or African ancestry. After correction for multiple testing, two interactions were significantly associated with diastolic BP. In European ancestry participants, outward/trait anger score had a significant interaction with the C10orf107 genomic region (p = 0.0019). In African ancestry participants, depressive symptom score had a significant interaction with the HFE genomic region (p = 0.0048). This study provides a foundation for using genomic region-based longitudinal analysis to identify subgroups of the population that may be at greater risk of elevated BP due to the combined influence of genetic and socioeconomic/psychosocial risk factors. %B Int J Environ Res Public Health %V 14 %G eng %N 12 %1 http://www.ncbi.nlm.nih.gov/pubmed/29258278?dopt=Abstract %R 10.3390/ijerph14121596