%0 Journal Article %J Alzheimer's research & therapy %D 2023 %T A longitudinal study of polygenic score and cognitive function decline considering baseline cognitive function, lifestyle behaviors, and diabetes among middle-aged and older US adults. %A Liu, Tingting %A Li, Changwei %A Zhang, Ruiyuan %A Millender, Eugenia Flores %A Miao, Hongyu %A Ormsbee, Michael %A Guo, Jinzhen %A Westbrook, Adrianna %A Pan, Yang %A Wang, Jing %A Kelly, Tanika N %K Adult %K Aged %K Apolipoproteins E %K Cognition %K Cognitive Dysfunction %K Diabetes Mellitus %K Humans %K Life Style %K Longitudinal Studies %K Middle Aged %X

BACKGROUND: Genomic study of cognition decline while considering baseline cognition and lifestyle behaviors is scarce. We aimed to evaluate the impact of a polygenic score for general cognition on cognition decline rate, while considering baseline cognition and lifestyle behaviors, among the general population and people with diabetes, a patient group commonly affected by cognition impairment.

METHODS: We tested associations of the polygenic score for general cognition with annual changing rates of cognition measures in 8 years of follow-up among 12,090 White and 3100 Black participants of the Health and Retirement Study (HRS), a nationally representative sample of adults aged 50 years and older in the USA. Cognition measures including word recall, mental status, and total cognitive score were measured biannually. To maximize sample size and length of follow-up, we treated the 2010 wave of survey as baseline, and follow-up data until 2018 were analyzed. Baseline lifestyle behaviors, APOE status, and measured cognition were sequentially adjusted. Given racial differences in polygenic score, all analyses were conducted by race.

RESULTS: The polygenic score was significantly associated with annual changing rates of all cognition measures independent of lifestyle behaviors and APOE status. Together with age and sex, the polygenic score explained 29.9%, 15.9%, and 26.5% variances of annual changing rates of word recall, mental status, and total cognitive scores among Whites and explained 17.2%, 13.9%, and 18.7% variance of the three traits among Blacks. Among both White and Black participants, those in the top quartile of polygenic score had the three cognition measures increased annually, while those in the bottom quartile had the three cognition measures decreased annually. After further adjusting for the average cognition assessed in 3 visits around baseline, the polygenic score was still positively associated with annual changing rates of all cognition measures for White (P ≤ 2.89E - 19) but not for Black (P ≥ 0.07) participants. In addition, among participants with diabetes, physical activity offset the genetic susceptibility to decline of mental status (interaction P ≤ 0.01) and total cognitive scores (interaction P = 0.03).

CONCLUSIONS: Polygenic score predicted cognition changes in addition to measured cognition. Physical activity offset genetic risk for cognition decline among diabetes patients.

%B Alzheimer's research & therapy %V 15 %P 196 %G eng %N 1 %R 10.1186/s13195-023-01343-1 %0 Journal Article %J Biological Research for Nursing %D 2022 %T The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States. %A Liu, Tingting %A Li, Hongjin %A Conley, Yvette P %A Primack, Brian A %A Wang, Jing %A Li, Changwei %K Brain-Derived Neurotrophic Factor %K Cognition %K Exercise %K Gene-Environment Interaction %K Hand Strength %X

INTRODUCTION: Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA).

METHODS: A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition.

RESULTS: Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, = .07), mental status (beta = 0.16, = .07), and word recall (beta = 0.22, =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = -0.09, = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model.

CONCLUSIONS: The Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

%B Biological Research for Nursing %V 24 %P 226-234 %G eng %N 2 %R 10.1177/10998004211065151 %0 Journal Article %J Clinical Nursing Research %D 2022 %T The Influence of the Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes. %A Zeng, Bin %A Yue, Yan %A Liu, Tingting %A Ahn, Hyochol %A Li, Changwei %K Brain-Derived Neurotrophic Factor %K Depressive symptoms %K Diabetes %K Grip strength %K Physical activity %X

The rs6265 in the (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = -.15) and stronger grip strength (β = -.02) were independently associated with depression. Although the interaction between rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = -.19) and male Met carriers (β = -.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = -.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.

%B Clinical Nursing Research %G eng %R 10.1177/10547738221119343 %0 Journal Article %J Biological Research for Nursing %D 2020 %T The Influence of the BDNFVal66Met Polymorphism on the Association of Regular Physical Activity With Cognition Among Individuals With Diabetes. %A Liu, Tingting %A Canon, McKenzie D %A Shen, Luqi %A Marples, Benjamin A %A Colton, Joseph P %A Lo, Wen-Juo %A Gray, Michelle %A Li, Changwei %K Brain-Derived Neurotrophic Factor %K Cognition %K Diabetes Mellitus %K Exercise %K Gene-Environment Interaction %X

INTRODUCTION: Diabetes is associated with cognitive dysfunction that comes with substantial lifetime consequences, such as interference with diabetes self-management and reduced quality of life. Although regular physical activity has been consistently shown to enhance cognitive function among healthy subjects, significant interpersonal differences in exercise-induced cognitive outcomes have been reported among (BDNF) Val/Val vs. Met carriers. However, the evidence on how the Val66Met variant influences the relationship between regular physical activity and cognition among individuals with diabetes is currently lacking.

METHODS: A total of 3,040 individuals with diabetes were included in this analysis using data from the Health and Retirement Study. Associations among moderate and vigorous physical activities (MVPA) and measures of cognitive function were evaluated using multivariable linear regression models within each stratum of the Val66Met genotypes.

RESULTS: MVPA was more strongly associated with total cognitive score, mental status, and words recall among Met/Met carriers, compared to Val/Val and Val/Met carriers.

CONCLUSIONS: This study provided preliminary findings on how variants may modulate the exercise-induced cognitive benefits among mid-aged and older adults with diabetes. Given the limitations of the current study, it is necessary for randomized controlled trials to stratify by genotypes to more conclusively determine whether Met carriers benefit more from increased physical activity. In addition, future research is needed to examine how the interplay of Val66Met variants, DNA methylation, and physical activity may have an impact on cognitive function among adults with diabetes.

%B Biological Research for Nursing %G eng %R 10.1177/1099800420966648